Talpade began his acting career appearing in Marathi soap operas and doing stage shows across Maharashtra. He also appeared in the Zee TV soap opera Woh (1997) in which he was the main lead. He has also acted in mini-serials for the production "Adhikari Brothers". His role, in a very popular Marathi serial Damini, as the character Tejas was very popular among Marathi audiences. He also appeared in Jaane Anjaane (2001) aired on doordarshan where he played the role of a son who had dislikes for his father because he felt that his father was the reason for his accident. Viewers liked the content of the same. Fame arrived after he made his Bollywood debut in Nagesh Kukunoor's Iqbal which was written by Vipul K Rawal in which he played the role of a deaf & mute youngster aspiring to be a cricketer. The film and his performance were well received by both audiences and critics. His next film was Kukunoor's Dor in which he played the comic role of a behroopiya, a man with many disguises. This film was also well received by critics.